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OCR: The best evidence that the cancer cacher ) produced syndrome is induced by humoral factor human by cancer cells is obtained by analyses of op severe tumour xenografts in mice, which deve brings cachexia; tumour resection in these mic about rapid regain of the lost weight. lis The hypothetical factor responsible for t hormone', syndrome, originally referred to as 'toxo tal studies has long been sought. Recent experimer hia and IL-6demonstrate that two cytokines, leukaer lidates for inhibitory factor, are the most likely can sponsible this syndrome. Since the mechanisms n actorial, for cachexia in cancer patients are multi in the evaluation of the role of these cytokines development of the syndrome is difficu.